Regenerative biology
Healing bodies through advanced science
This involves growing cells, biological scaffolds (repairing bones) and the use of pre-clinical animal models.
The Division collaborates with The Centre for Cell Therapy and Regenerative Medicine (CCTRM) and the Institute For Respiratory Health (IRH).
Research specialisations
Skeletal biology and regeneration
Looks at stem cells, burn pathology, the development of skin bio-scaffolds, skin healing and the inhibition of scar formation. Studies include:
- Osteoimmunology, osteolysis, and mechanisms of bone resorption
- Bone marrow-derived mesenchymal stem cells and pericytes
- Screening of natural compounds for the treatment of osteoporosis
- Deciphering the molecular basis of musculoskeletal diseases using ENU-induced mutant mice and collaborative cross mice
- Intercellular communication and angiogenic potential of endothelial progenitor cells in bone microenvironment
Lung biology, fibrosis and tissue regeneration
Explores lung fibrosis and its molecular mechanisms, lung injury repair, and stem cells homing.
Skin biology and regeneration
Examines stem cells, burn pathology, the development of skin bio-scaffolds, skin healing and the inhibition of scar formation.
Funding
2018
NHMRC Project Grants
- The Role of 'Orphan' Transporters in Bone Homeostasis and Disease
- Nathan Pavlos, Jiake Xu
2017
University of South Australia ex NHMRC
- NT-3 as an upstream and potentially master regulator promoting bone fracture healing
- Professor Cory Xian, Associate Professor Bruce Foster, Winthrop Professor Jiake Xu
2017-2020
NHMRC Project Grants
- Epithelial-Mesenchymal cell communication; towards new therapeutic targets for fibrosis
- Dr Cecilia Prele, Professor Darryl Knight, Dr Mark Fear, Dr Robin McAnulty, Professor Fiona Wood, Professor Geoff Laurent
2016
NHMRC Project Grants
- Gene mining for novel molecular determinants of the skeleton
- Winthrop Professor Jiake Xu, Associate Professor Nathan Pavlos, Dr Jennifer Tickner, Dr Scott Wilson, Dr John Walsh
Wound Management Innovation CRC
- Post-burn healing: Quantifying optimal compression therapy
- Professor Fiona Wood, Dr Sarah McGarry, Ms Rosemary Kendell
2015
NHMRC Project Grants
- Furin: Carving-up vital substrates for bone remodelling and homeostasis
- Winthrop Professor Jiake Xu, Associate Professor Nathan Pavlos, Dr Jennifer Tickner
Pharmaxis Ltd
- Targeting collagen cross-linking to improve scar appearance
- Professor Fiona Wood, Dr Wolfgang Jarolimek, Dr Mark Fear, Dr Killugudi Swaminatha Iyer
Telethon New Children’s Hospital Research Fund
- TPCHRF - Chronic immune suppression in paediatric burn survivors
- Professor Fiona Wood, Dr Vanessa Fear, Dr Mark Fear
