Dr Jeremy Shaw
- Contact details
The University of Western Australia (M010)
35 Stirling Highway
CRAWLEY WA 6009
- +61 8 6488 8059
- +61 8 6488 1087
- Personal homepage
- Room 1.61, Physics Building, Crawley campus
- BSc PhD Murd.
- Dr Jeremy Shaw has a Ph.D. in marine and biological sciences. His principal research interests involve the study of the cellular and organic matrix driven processes of invertebrate biomineralisation. Dr Shaw’s main field of expertise is in electron microscopy (TEM and SEM), coupled with analytical techniques such as electron energy loss spectroscopy (EELS) and energy-filtered TEM (EFTEM)in biology. In 2014, Dr Shaw has taken over as lead academic in charge of the CMCAs X-ray microscope facility (also known as micro-CT)
- Key research
- •Invertebrate biomineralisation
- •Marine invertebrate ecology and physiology
- •Biological sample preparation (cryo and microwave)
- •Ultrastructural anatomy of cells
- •Marine biology
- •Magnetic based navigation in organisms
- Book Chapters
Sato-Okoshi W, Abe H, Okoshi K, Teramoto W, Shaw J, Koh BS, Kim Y-H, Hong J-S and Li J-Y 2015 Harmful Shell Borers, Polydora Species (Polychaeta: Spionidae), from Commercially Important Mollusk Shells in East Asia and Australia. In Marine Productivity: Perturbations and Resilience of Socio-ecosystems (eds. H-J Ceccaldi Y Hénocque Y Koike T Komatsu G Stora & M-H Tusseau-Vuillemin), pp. 31-42, Springer International Publishing.
Saunders M and Shaw JA (2014) Biological application of energy-filtered TEM. In: Electron microscopy: methods and protocols, 3rd ed. Methods in Molecular Biology no. 1117. Kuo J. (ed), 689-706 Springer/Humana Press, New York /Totowa, NJ.
Lesley R. Brooker and Jeremy A. Shaw (2012). The Chiton Radula: A Unique Model for Biomineralization Studies, Advanced Topics in Biomineralization, Jong Seto (Ed.), ISBN: 978-953-51-0045-4, InTech, Available from: http://www.intechopen.com/articles/show/title/the-chiton-radula-a-unique-model-for-biomineralization-studies
Shaw J, Boyd A, House M, Woodward R, Mathes F, Cowin G, Saunders M, Baer B (2015) Magnetic particle-mediated magnetoreception. J. R. Soc. Interface 12: 20150499. http://dx.doi.org/10.1098/rsif.2015.0499
Edelman NB, Fritz T, Nimpf S, Pichler P, Lauwers M, Hickman RW, Papadaki-Anastasopoulou A, Ushakova L, Heuser T, Resch GP, Saunders M, Shaw JA, Keays DA 2015 No evidence for intracellular magnetite in putative vertebrate magnetoreceptors identified by magnetic screening. Proceedings of the National Academy of Sciences of the United States of America 112, 262-267. (doi:10.1073/pnas.1407915112).
Reisser J, Shaw JA, Hallegraeff G, Proietti M, Barnes DKA, Thums M, Wilcox C, Hardesty BD, Pattiaratchi C (2014) Millimeter-Sized Marine Plastics: A New Pelagic Habitat for Microorganisms and Invertebrates, PLOS ONE, 9 (6): e100289
Lozić I, Bartlett CA, Shaw JA, Iyer KS, Dunlop SA, Kilburn MR and Fitzgerald M (2014) Changes in subtypes of Ca microdomains following partial injury to the central nervous system. Metallomics 6(3) 455-464.
O’Brien S, Shaw JA, Zhao X, Abbott PV, Loc J, Munroe P, Habibi D and Xie Z (2014) Size dependent elastic modulus and mechanical resilience of dental enamel. Journal of Biomechanics. 47 (5) 1060-1066.
Weis C, Blank F, West A, Black G, Woodward RC, Carroll MRJ, Kartmann R, Hallam E, Shaw JA, Murphy J, Teoh WY, Aifantis KE, Amal R, House M, St Pierre T, Fabry B (2014) Labeling of cancer cells with magnetic nanoparticles for magnetic resonance imaging. Magnetic Resonance in Medicine DOI: 10.1002/mrm.24832.
Zhao,X, O’Brien S, Shaw JA, Abbott P, Munroe P, Habibi D and Xie Z (2013)The origin of remarkable robustness of human tooth enamel. Applied Physics Letters 103 241901 1-5.
Reisser J, Shaw JA, Wilcox C, Hardesty BD, Proietti M, Thums M, Pattiaratchi C (2013) Marine plastic pollution in waters around Australia: characteristics, concentrations, and pathways. PloS ONE 8 (11) e80466.
Paterson SM, Shadforth AMA, Shaw JA, Brown DH, Chirila TV, Baker MV (2013) Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges. Materials Science and Engineering C 33 4917-4922.
Lauwers M, Pichler P, Edelman NB, Resch GP, Ushakova L, Salzer MC, Heyers D, Saunders M, Shaw JA, Keays DA (2013) An iron-rich organelle in the cuticular plate of avian hair cells. Current Biology DOI: 10.1016/j.cub.2013.04.025.
Karl S, Gutiérrez L, Lucyk-Maurer R, Kerr R, Candido RRF, Toh SQ, Saunders M, Shaw JA, Suvorova A, Hofmann A, House MJ, Woodward RC, Graeff-Teixera C, St. Pierre TG, Jones MK (2013) The iron distribution and magnetic properties of schistosome eggshells: implications for improved diagnostics. PLOS Neglected Tropical Diseases DOI: 10.1371/journal.pntd.0002219.
Wedlock LE, Kilburn MR, Liu R, Shaw JA, Berners-Price SJ, Farrell NP (2013) NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound. Chemical Communications DOI: 0.1039/C3CC42098A.
Saville SL, Woodward RC, House MJ, Tokarev A, Hammers J, Qi B, Shaw JA, Saunders M, Varsani RR, St Pierre TG and Mefford TO (2013) The effect of magnetically induced linear aggregates on proton transverse relaxation rates of aqueous suspensions of polymer coated magnetic nanoparticles. Nanoscale 5: 2152-2163.
Paterson SM, Casadio YS, Brown DH, Shaw JA, Chirila TV and Baker MV (2013) Laser scanning confocal microscopy versus scanning electron microscopy for characterization of polymer morphology: Sample preparation drastically distorts morphologies of poly(2-hydroxyethyl methacrylate)-based hydrogels. J. Appl. Poly. Sys. 127: (6) 4296-4304.
Treiber, C.D., Salzer, M.C., Riegler, J., Edelman, N., Sugar, C., Breuss, M., Pichler, P., Cadiou, H., Saunders, M., Lythgoe, M., Shaw, J. & Keays, D.A. (2012). Clusters of iron-rich cells in the upper beak of pigeons are macrophages not magnetosensitive neurons. Nature 484(7394), 367-370.
Paterson SM, Brown DH, Shaw JA, Chirila TV and Baker, MV (2012) The Synthesis of PHEMA sponges via ARGET ATRP. Aust. J. Chem. 65:931-934
Wells, J, Kilburn, M, Shaw, JA, Bartlett, C, Harvey, A, Dunlop, S, Fitzgerald, M. (2012) Early in vivo changes in calcium ions, oxidative stress markers and ion channel immunoreactivity following partial injury to the optic nerve. Journal of Neuroscience Research, 90: 606-618.
Evans, C, Fitzgerald, M, Clemons, T, House, M, Padman, B, Shaw, JA, Saunders, M, Harvey, A, Zdyrko, B, Luzinov, I, Silva, GA, Dunlop, S, Iyer, KS (2011) Multimodal Analysis of PEI-Mediated Endocytosis of Nanoparticles in Neural Cells. ACS Nano 5 (11): 8640-8648.
Saunders, M, Kong, C, Shaw, JA, Clode, PL (2011) Matrix-mediated biomineralization in marine mollusks: A combined transmission electron microscopy and focused ion beam approach. Microscopy & Microanalysis 17 (2): 220-225.
Usher, KM, Shaw, JA, Kaksonen, AH, Saunders, M (2010) Elemental analysis of extracellular polymeric substances and granules in chalcopyrite bioleaching microbes. Hydrometallurgy 104: 376-381.
Carson, JK, Gonzalez-Quinones, V, Murphy, DV, Hinz, C, Shaw, JA, Gleeson, DB (2010) Low pore connectivity increases bacterial diversity in soil. Applied and Environmental Microbiology, 76: 12, 3936-3942.
Shaw JA, Macey DJ, Brooker LR, Clode PL (2010). Tooth use and wear in three iron biomineralizing mollusc species. Biological Bulletin 218: 132-144. (1.924, Marine and Freshwater Biology, 23/87).
Shaw JA, Macey DJ, Brooker LR, Stockdale EJ, Saunders M, Clode PL (2009). The chiton stylus canal: An element delivery pathway for tooth cusp biomineralization. Journal of Morphology 270: 588-600. (1.711, Anatomy and Morphology, 7/17).
Shaw JA, Macey DJ, Brooker LR, Stockdale EJ, Saunders M, Clode PL (2009). Ultrastructure of the epithelial cells associated with tooth biomineralization in the chiton Acanthopleura hirtosa. Microscopy and Microanalysis 15: 154-165. (2.790, Microscopy, 1/9).
Saunders M, Kong C, Shaw JA, Macey DJ, Clode PL (2009). Characterization of biominerals in the radula teeth of the chiton, Acanthopleura hirtosa. Journal of Structural Biology 167: 55-61. (3.964, Biophysics, 15/71).
Stockdale EJ, Shaw JA, Macey DJ, Clode PL (2009). Imaging organic and mineral phases in a biomineral using novel contrast techniques. Scanning 31: 11-18. (0.929, Instruments and Instrumentation, 26/56).
Shaw JA, Macey DJ, Brooker LR (2008). Radula synthesis by three species of iron mineralizing molluscs: production rate and elemental demand. Journal of the Marine Biological Association of the United Kingdom 88: 597-601. (1.187, Marine and Freshwater Biology, 54/87).
Shaw JA, Macey DJ, Clode PL, Brooker LR, Webb RI, Stockdale EJ, Binks RM (2008). Methods of sample preparation of radula epithelial tissue in chitons (Mollusca: Polyplacophora). American Malacological Bulletin 25: 35-41. (0.692, Marine and Freshwater Biology, 82/87).
Sato-Okoshi W, Okoshi K, Shaw J (2008). Polydorid species (Polychaeta: Spionidae) in south-western Australian waters with special reference to Polydora uncinata and Boccardia knoxi. Journal of the Marine Biological Association of the UK 88: 491-501. (1.187, Marine and Freshwater Biology, 54/87).
Shaw, JA, Brooker, LR, Macey, DJ (2002). Radular tooth turnover in the chiton Acanthopleura hirtosa (Blainville, 1825) (Mollusca: Polyplacophora). Molluscan Research 22: 93-99.
- Roles, responsibilities and expertise
- X-ray microscopy (micro-computed tomography)
Cryo-preparation for biological electron microscopy. Including high-pressure freezing, freeze-substitution and cryo-microtomy.
Areas of Expertise:
•Biological sample preparation for TEM and SEM
•Microscopy (LM, TEM, SEM)
•Analytical microscopy (X-ray microanalysis (EDS), EELS, EFTEM)
•Microtomy (wax, semi, ultra-thin, cryo-sectioning)
- Future research
- Biomaterials research holds great promise for developing novel structures that link organic and inorganic systems. Biominerals, such as teeth, shell or bone are obvious models for this research. These natural materials have many desirable properties that stem from their hierarchical design, where structural units interact across multiple length scales, imparting superior strength and flexibility compared to synthetic analogues. Biominerals have evolved over millions of years to perform a wide variety of specific functions in nature. Structurally, biominerals are highly sophisticated, and by studying how they are formed it may be possible to reverse engineer the process, leading to the design of new biocompatible materials. The particular model for my research is the chiton, a marine mollusc that hardens its teeth with magnetite, one of the hardest and most magnetic iron oxides known.
- Funding received
- ARC Discovery Early Career Research Award (Shaw) The secret of bee navigation: Magnetic field sensitive cells in the honeybee Apis Mellifera. ($375,000)
UWA-UQ Bilateral Research Award (Shaw, House, Cowin): Animal magnetism: The search for magnetoreceptive cells in the honeybee. ($13,688)
UWA RDA (Shaw): The search for a true sixth sense: Identifying magnetoreceptive cells in animals ($23,055)
UWA Research Collaboration Award with Prof. Chris Hawkesworth, Bristol University and Prof John Cliff, CMCA, ‘Iron biominerals: Proxies for characterising ancient oceans and climate change’; Value $10,000; 2010.
• 4 x AMMRF Travel and Access awards ‘Cryo-microtomy of frozen hydrated samples and immunogold labelling’, ‘Identification of the mineral phases of chiton teeth’ and ‘Cryopreservation of radular superior epithelial tissue in the chiton Acanthopleura hirtosa (Mollusca: Polplacophora) by high pressure freezing’; Value $8000; 2008/09.
• UWA Early Career Research Development Award ‘Inspired by nature: Investigating tooth mineralisation as a model for the development of new materials with biomimetic properties’; Value $29,000; 2008/09.
• Swan River Trust SCRIP grant ‘The chiton fauna of the Swan River Estuary and their potential role as indicators of environmental contamination’; Value $19,000; 2008/09.
- Industrial relevance
- Biomaterials are of enormous commercial importance to Australian industry, as recognised under the ARC’s research priority, “Frontier Technologies for Building and Transforming Australian Industries”. Fundamental research on biomineralisation clearly sits within the mandate of this vision, with chitons providing an innovative model for the study of a process that holds significant promise for the development of advanced materials. By definition, biomaterials span the interface between materials science and biology, often merging inorganic and organic systems. No clearer field bridges this gap than that of biomineralisation. Current trends in biomaterials science involve the design of new devices from the molecular level upward, with increasing levels of structural complexity at a range of length scales. This is precisely what chitons have perfected over millions of years of evolution. As such, understanding the crystallographic and molecular basis of the biomineralisation process could provide a novel route in materials chemistry and nanotechnology for the future fabrication of new materials.
- Australian Microscopy and Microanalysis Society
Microscopy Society of America
Australian Malacology Society
American Malacology Society
Australian Marine Science Association.
- Honours and awards
- Trans Tasman Award 2012 - Australian Microscopy and Microanalysis Society
Robert P. Apkarian Memorial Scholarship 2009 - Microscopy Society of America.
David Goodchild Award 2008 - Australian Microscopy and Microanalysis Society.
Ron Kenny Award 2002 - Australian Marine Science Association
- Biophysics - Introduction to Light and Electron Microscopy